Iziguli ezinokwehluleka kwezinso zidinga i-dialysis evamile, okuwukwelashwa okuhlaselayo futhi okungaba yingozi.Kodwa manje abacwaningi baseNyuvesi yaseCalifornia, eSan Francisco (UCSF) babonise ngempumelelo izinso ze-prototype bioartificial ezingafakwa futhi zisebenze ngaphandle kwesidingo sezidakamizwa.
Inso yenza imisebenzi eminingi ebalulekile emzimbeni, okuphawuleka kakhulu ukuhlunga ubuthi nemikhiqizo emoshayo egazini, iphinde ilawule umfutho wegazi, ukugcwala kwe-electrolyte nolunye uketshezi lomzimba.
Ngakho-ke, lapho lezi zitho ziqala ukwehluleka, kuba nzima kakhulu ukuphindaphinda lezi zinqubo.Iziguli zivame ukuqala nge-dialysis, kodwa lokhu kudla isikhathi futhi akukhululekile.Isixazululo sesikhathi eside ukufakelwa kwezinso, okungabuyisela izinga eliphezulu lokuphila, kodwa kuhambisana nesidingo sokusebenzisa izidakamizwa ze-immunosuppressive ukuvimbela imiphumela eyingozi yokwenqatshwa.
Kuphrojekthi yezinso ze-UCSF, ithimba lenze izinso ze-bioartificial ezingafakwa ezigulini ukuze zenze imisebenzi eyinhloko yezinto zangempela, kodwa azidingi izidakamizwa ezivimbela ukuzivikela komzimba noma izidakamizwa zegazi, ezivame ukudingeka.
Idivayisi iqukethe izingxenye ezimbili eziyinhloko.Isihlungi segazi sakhiwe ngolwelwesi lwe-silicon semiconductor, olungasusa udoti egazini.Ngesikhathi esifanayo, i-bioreactor iqukethe amangqamuzana e-renal tubular akhiwe akwazi ukulawula umthamo wamanzi, ibhalansi ye-electrolyte kanye neminye imisebenzi ye-metabolic.Ulwelwesi luphinde luvikele la mangqamuzana ekuhlaselweni amasosha omzimba esiguli.
Ukuhlola kwangaphambilini kuvumele ingxenye ngayinye yalezi zici ukuthi isebenze ngokuzimela, kodwa kungokokuqala ukuthi ithimba lizihlole ukuthi zisebenze ndawonye kudivayisi.
Inso ye-bioartificial ixhunywe emithanjeni emibili eyinhloko esemzimbeni wesiguli - enye ithwala igazi elihlungiwe iliyise emzimbeni bese enye ithwala igazi elihlungiwe ilibuyisele emzimbeni - nasesinyeni, lapho imfucuza ifakwa ngendlela yomchamo.
Ithimba manje lenze ukuhlolwa kobufakazi bomqondo, okubonisa ukuthi izinso ze-bioartificial zisebenza kuphela ngaphansi komfutho wegazi futhi ayidingi iphampu noma umthombo wamandla wangaphandle.Amaseli e-renal tubular ayaphila futhi ayaqhubeka nokusebenza phakathi nokuhlolwa.
Ngenxa yemizamo yabo, abacwaningi baseNyuvesi yaseCalifornia, eSan Francisco manje sebethole umklomelo we-KidneyX $650,000 njengomunye wabaphumelele esigabeni sokuqala somklomelo wezinso zokwenziwa.
UShuvo Roy, umcwaningi oholayo walo msebenzi, uthe: “Ithimba lethu laklama izinso zokwenziwa ezingasekela ngokuqhubekayo ukutshalwa kwamangqamuzana ezinso zomuntu ngaphandle kokubangela ukusabela komzimba.”Ngokunokwenzeka kwenhlanganisela ye-reactor, singagxila ekuthuthukiseni ubuchwepheshe ukuze sihlole ukuhlolwa kwangaphambi komtholampilo futhi ekugcineni kube nezivivinyo zomtholampilo.”