Abacwaningi abavela eMnyangweni Wezobunjiniyela Bemishini Nezindiza (MAE) weSikole Sobunjiniyela sase-Herbert Wertheim benze uhlobo olusha lwe-hemodialysis membrane eyenziwe nge-graphene oxide (GO), okuwumsebenzi ongqimba we-monoatomic.Kulindeleke ukuthi kuguqule ngokuphelele ukwelashwa kwe-dialysis yezinso ngesineke.Lokhu kuthuthuka kuvumela i-microchip dialyzer ukuthi inamathele esikhumbeni sesiguli.Isebenza ngaphansi komfutho wegazi, izoqeda iphampu yegazi kanye nesekhethi yegazi engaphandle komzimba, ivumele i-dialysis ephephile endaweni yokunethezeka kwekhaya lakho.Uma kuqhathaniswa nolwelwesi olukhona lwe-polymer, ukungeneka kolwelwesi kungama-oda amabili obukhulu obuphakeme, kunokuhambisana negazi, futhi akulula ukukala njengolwelwesi lwe-polymer.
USolwazi Knox T. Millsaps we-MAE kanye nomcwaningi oholayo wephrojekthi ye-membrane uSaeed Moghaddam nethimba lakhe basungule inqubo entsha ehilela ukuzihlanganisa kanye nokwenza kahle kwezakhiwo zomzimba namakhemikhali ze-GO nanoplatelet.Le nqubo ishintsha kuphela izendlalelo ezingu-3 ze-GO zibe ama-nanosheet ama-nanosheet ahleleke kakhulu, ngaleyo ndlela azuze ukufinyeleleka okuphezulu nokukhetha."Ngokwakha ulwelwesi olukwazi ukungena kalula kunozakwabo webhayoloji, i-glomerular basement membrane (GBM) yezinso, sibonise amandla amakhulu okuzihlanganisa kwama-nanomaterials, ama-nanoengineering, kanye nama-molecule."Mogda uDkt. Mu uthe.
Ucwaningo lokusebenza kolwelwesi ezimeni ze-hemodialysis luveze imiphumela ekhuthaza kakhulu.Ama-sieving coefficients we-urea ne-cytochrome-c angu-0.5 no-0.4, ngokulandelana, anele ukudayela kancane kwesikhathi eside kuyilapho egcina ngaphezu kuka-99% we-albumin;izifundo ze-hemolysis, ukupheleliswa kokusebenza kanye nokuhlangana kubonise ukuthi ziqhathaniswa nezinto ezikhona ze-dialysis membrane Noma zingcono kunokusebenza kwezinto ezikhona ze-dialysis membrane.Imiphumela yalolu cwaningo ishicilelwe kokuthi Advanced Materials Interfaces (Februwari 5, 2021) ngaphansi kwesihloko esithi "Trilayer Interlinked Graphene Oxide Membrane for Wearable Hemodialyzer".
UDkt. Moghaddam wathi: “Sibonise i-mosaic e-odiwe ye-GO nanoplatelet eyingqayizivele eyingqayizivele, ewuthuthukisa kakhulu umzamo weminyaka eyishumi wokwakhiwa kolwelwesi olusekelwe ku-graphene.”Kuyinkundla esebenzayo engathuthukisa i-dialysis yasebusuku egeleza kancane ekhaya. ”UDkt. Moghaddam njengamanje usebenzela ukuthuthukiswa kwama-microchips esebenzisa ulwelwesi olusha lwe-GO, oluzosondeza ucwaningo eqinisweni lokuhlinzeka ngemishini egqokekayo ye-hemodialysis ezigulini ezinesifo sezinso.
Isihloko somhleli we-Nature (March 2020) sathi: “I-World Health Organization ilinganisela ukuthi cishe abantu abayizigidi ezingu-1.2 bafa ngenxa yokungasebenzi kwezinso unyaka ngamunye emhlabeni wonke [futhi izehlakalo ze-end-stage renal disease (ESRD) zibangelwa isifo sikashukela nomfutho wegazi ophakeme]….I-Dialysis Inhlanganisela yemikhawulo ebonakalayo yobuchwepheshe kanye nokufinyeleleka kwayo kusho ukuthi bangaphansi kwengxenye yabantu abadinga ukwelashwa abakwaziyo ukuyifinyelela.”Imishini emincane egqokekayo efanelekile iyisixazululo esinomnotho sokukhulisa amazinga okusinda, ikakhulukazi ekuthuthukisweni kwe-China."I-membrane yethu iyingxenye ebalulekile yesistimu egqokekayo encane, engakhiqiza kabusha umsebenzi wokuhlunga wezinso, ukuthuthukisa kakhulu ukunethezeka nokufinyeleleka emhlabeni jikelele," kusho uDkt. Moghaddam.
“Intuthuko enkulu ekwelashweni kweziguli ezine-hemodialysis kanye nokwehluleka kwezinso kunqunyelwe ubuchwepheshe be-membrane.Ubuchwepheshe be-Membrane abuzange benze inqubekelaphambili ebalulekile emashumini ambalwa eminyaka adlule.Intuthuko eyisisekelo yobuchwepheshe be-membrane idinga ukuthuthukiswa kwe-renal dialysis.Izinto ezingeneka kakhulu nezikhethiwe, njenge-ultra-thin graphene oxide membrane eyakhiwe lapha, ingase iguqule ipharadigm.Ama-membrane amancane angakwazi ukubona kuphela ama-dialyzer amancane, kodwa futhi namadivaysi angempela aphathekayo futhi agqokekayo, ngaleyo ndlela athuthukise izinga lempilo kanye nokubikezelwa kwesiguli. "UJames L. McGrath uthe unguprofesa wobunjiniyela bezinto eziphilayo eNyuvesi yaseRochester futhi ungumsunguli wobuchwepheshe obusha bolwelwesi obuncane be-silicon obusetshenziselwa ukusetshenziswa okuhlukahlukene kwezinto eziphilayo (Imvelo, i-2007).
Lolu cwaningo luxhaswe yiNational Institute of Biomedical Imaging and Bioengineering (NIBIB) ngaphansi kweNational Institutes of Health.Ithimba likaDkt. Moghaddam lihlanganisa uDkt. Richard P. Rode, uzakwabo owathola iziqu zobudokotela e-UF MAE, uDkt. Thomas R. Gaborski (umseshi oyinhloko), u-Daniel Ornt, MD (umseshi oyinhloko), kanye no-Henry C woMnyango Wezempilo. Ubunjiniyela, i-Rochester Institute of Technology.UDkt. Chung noHayley N. Miller.
UDkt. Moghaddam uyilungu le-UF Interdisciplinary Microsystems Group futhi uhola i-Nanostructured Energy Systems Laboratory (NESLabs), injongo yayo kuwukuthuthukisa izinga lolwazi le-nanoengineering yezakhiwo ezisebenza kahle ezimbotshana kanye ne-micro/nanoscale transmission physics.Uhlanganisa ndawonye imikhakha eminingi yobunjiniyela nesayensi ukuze aqonde kangcono i-physics ye-micro/nano-scale transmission futhi athuthukise izakhiwo nezinhlelo zesizukulwane esilandelayo ngokusebenza okuphezulu nokusebenza kahle.
I-Herbert Wertheim College of Engineering 300 Weil Hall PO Box 116550 Gainesville, FL 32611-6550 Inombolo yocingo yasehhovisi